Lionel Messi had a hand in all six goals while Luis Suarez scored a hat-trick as Inter Miami overcame the New York Red Bulls 6-2 at Chase Stadium.
The Eastern Conference leaders were on a three-match winning streak in MLS, but fell behind to Dante Vanzeir s opener in the 30th minute.
However, the hosts turned the match on its head after the break, with Messi assisting a brace for half-time substitute Matias Rojas either side of getting on the scoresheet himself.
Suarez then took centre stage with a hat-trick inside 13 minutes all assisted by his former Barcelona team-mate while Emil Forsberg s stoppage-time penalty was a mere consolation for the visitors, who are now without a win in four.
Lionel Messi s six goal contributions for tonight set a record for the most in a single game in MLS history.
Messi s five assists were also the most by a player in a game in MLS history.
— MLS Communications (@MLS_PR)
Data debrief
Messi broke two more MLS records following yet another inspirational display for the Herons.
The eight-time Ballon d Or winner s six goal contributions and five assists were both the most recorded by a player in a single game.